E-ISSN 2636-3003 | ISSN 2636-2996
 

Original Research (Original Article) 


Biochemical alterations associated with experimentally induced breast cancer in rats

Zeweil, M.M., Taha, N.M., Sadek, K.M., El- Sayed, Y.S., Nasr, S.M..

Abstract
This study was conducted to demonstrate the preventive graviola effect on breast cancer induced by 7,12-dimethylbenz [a] anthracene (DMBA) in fifty female rats distributed into four groups. Group I: Control group injected orally by physiological saline, group II: DMBA induced-breast cancer, injected by a single dose of DMBA (50mg/kg) diluted in sesame oil (1 ml) given orally by gavage, group III: Graviola 200 mg/kg two times per week given orally by gavage from the first day of the experiment till the end plus a single dose of DMBA (50mg/kg) diluted in sesame oil (1mL) given orally at age of 57 days and group IV: rats treated with single dose of DMBA (50mg/kg) diluted in sesame oil (1mL) given orally plus graviola 200 mg/kg two times weekly both at age of 57 days till the end. After 30w the animals were anaesthetized to collect blood samples to determine the hepatic and renal protection of graviola. Treatment with graviola significantly (p< 0.05) reduced ALT activity and creatinine level. We can conclude that graviola mitigated hepatic and kidney functions.

Key words: Breast cancer; graviola, liver; kidney, histopathology, body weight.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Zeweil
Articles by M.M.
Articles by Taha
Articles by N.M.
Articles by Sadek
Articles by K.M.
Articles by El- Sayed
Articles by Y.S.
Articles by Nasr
Articles by S.M.
on Google
on Google Scholar
Article Statistics
 Viewed: 201
Downloaded: 30
Cited: 0

How to Cite this Article
Pubmed Style

, M.M. , Taha , N.M. , Sadek , K.M. , Sayed E, Y.S. , Nasr , S.M. . Biochemical alterations associated with experimentally induced breast cancer in rats. DJVS. 2019; 1(2): 11-13. doi:10.5455/DJVS.32001


Web Style

, M.M. , Taha , N.M. , Sadek , K.M. , Sayed E, Y.S. , Nasr , S.M. . Biochemical alterations associated with experimentally induced breast cancer in rats. http://www.damanhourjvetsci.com/?mno=32001 [Access: March 24, 2019]. doi:10.5455/DJVS.32001


AMA (American Medical Association) Style

, M.M. , Taha , N.M. , Sadek , K.M. , Sayed E, Y.S. , Nasr , S.M. . Biochemical alterations associated with experimentally induced breast cancer in rats. DJVS. 2019; 1(2): 11-13. doi:10.5455/DJVS.32001



Vancouver/ICMJE Style

, M.M. , Taha , N.M. , Sadek , K.M. , Sayed E, Y.S. , Nasr , S.M. . Biochemical alterations associated with experimentally induced breast cancer in rats. DJVS. (2019), [cited March 24, 2019]; 1(2): 11-13. doi:10.5455/DJVS.32001



Harvard Style

, M.M., ., Taha, ., N.M., ., Sadek, ., K.M., ., Sayed, . E., Y.S., ., Nasr, . & S.M., . (2019) Biochemical alterations associated with experimentally induced breast cancer in rats. DJVS, 1 (2), 11-13. doi:10.5455/DJVS.32001



Turabian Style

, M.M., Taha, N.M., Sadek, K.M., El- Sayed, Y.S., Nasr, and S.M.. 2019. Biochemical alterations associated with experimentally induced breast cancer in rats. Damanhour Journal of Veterinary Sciences, 1 (2), 11-13. doi:10.5455/DJVS.32001



Chicago Style

, M.M., Taha, N.M., Sadek, K.M., El- Sayed, Y.S., Nasr, and S.M.. "Biochemical alterations associated with experimentally induced breast cancer in rats." Damanhour Journal of Veterinary Sciences 1 (2019), 11-13. doi:10.5455/DJVS.32001



MLA (The Modern Language Association) Style

, M.M., Taha, N.M., Sadek, K.M., El- Sayed, Y.S., Nasr, and S.M.. "Biochemical alterations associated with experimentally induced breast cancer in rats." Damanhour Journal of Veterinary Sciences 1.2 (2019), 11-13. Print. doi:10.5455/DJVS.32001



APA (American Psychological Association) Style

, M.M., ., Taha, ., N.M., ., Sadek, ., K.M., ., Sayed, . E., Y.S., ., Nasr, . & S.M., . (2019) Biochemical alterations associated with experimentally induced breast cancer in rats. Damanhour Journal of Veterinary Sciences, 1 (2), 11-13. doi:10.5455/DJVS.32001