E-ISSN 2636-3003 | ISSN 2636-2996
 

Original Research (Original Article) 


Role of melatonin in preventing thioacetamide induced liver injury in rats

Abdou, S.E., Taha, N.M., Lebda, M.A., El Hoffy, H.R., Hashem, A.E..

Abstract
Liver is a vital organ necessary for survival, synthesizing crucial molecules including cholesterol, glucose and fatty acids. Moreover, it makes most plasma proteins including albumin so its injury or damage leads to disturbance of their blood concentration. Thioacetamide (TAA) established liver fibrosis model with histopathological appearance that is similar to human cirrhosis however, melatonin considered as one of anti- fibrotic agents through its anti-inflammatory and antioxidant functions, so we aimed to investigate the possible correction role of melatonin on altered serum proteins and liver histopathology on rats with induced liver injury. Sixty male albino rats were classified to equal 4 groups as follows: control, melatonin group (5mg/kg b.w/i.p), TAA group (150 mg/kg b.w/i.p) and TAA + melatonin group after 60 days, the animals were anaesthetized to collect blood samples for determination of serum protein concentrations, and liver tissues were collected for histopathological examination.Key finding, liver injury induced by TAA causedmarked decrease on serum protein and albumin, this injury was confirmed by histopathological examination that showed interlobular and intralobular cirrhosis associated with severe degree of hepatic vacuolation, On the other hand melatonin successfully improved the serious effects of TAA on liver function through ameliorating the decrease in total protein and albumin concentration along with restoring altered histopathological changes toward normal again. Our study concluded that co- treatment with melatonin may be favorable in protection from hepatic injury caused by TAA.

Key words: liver fibrosis; total protein, histopathology


 
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How to Cite this Article
Pubmed Style

, S.E. , Taha , N.M. , Lebda , M.A. , Hoffy E, H.R. , Hashem , A.E. . Role of melatonin in preventing thioacetamide induced liver injury in rats. DJVS. 2019; 1(2): 18-21. doi:10.5455/DJVS.42702


Web Style

, S.E. , Taha , N.M. , Lebda , M.A. , Hoffy E, H.R. , Hashem , A.E. . Role of melatonin in preventing thioacetamide induced liver injury in rats. http://www.damanhourjvetsci.com/?mno=42702 [Access: August 26, 2019]. doi:10.5455/DJVS.42702


AMA (American Medical Association) Style

, S.E. , Taha , N.M. , Lebda , M.A. , Hoffy E, H.R. , Hashem , A.E. . Role of melatonin in preventing thioacetamide induced liver injury in rats. DJVS. 2019; 1(2): 18-21. doi:10.5455/DJVS.42702



Vancouver/ICMJE Style

, S.E. , Taha , N.M. , Lebda , M.A. , Hoffy E, H.R. , Hashem , A.E. . Role of melatonin in preventing thioacetamide induced liver injury in rats. DJVS. (2019), [cited August 26, 2019]; 1(2): 18-21. doi:10.5455/DJVS.42702



Harvard Style

, S.E., ., Taha, ., N.M., ., Lebda, ., M.A., ., Hoffy, . E., H.R., ., Hashem, . & A.E., . (2019) Role of melatonin in preventing thioacetamide induced liver injury in rats. DJVS, 1 (2), 18-21. doi:10.5455/DJVS.42702



Turabian Style

, S.E., Taha, N.M., Lebda, M.A., El Hoffy, H.R., Hashem, and A.E.. 2019. Role of melatonin in preventing thioacetamide induced liver injury in rats. Damanhour Journal of Veterinary Sciences, 1 (2), 18-21. doi:10.5455/DJVS.42702



Chicago Style

, S.E., Taha, N.M., Lebda, M.A., El Hoffy, H.R., Hashem, and A.E.. "Role of melatonin in preventing thioacetamide induced liver injury in rats." Damanhour Journal of Veterinary Sciences 1 (2019), 18-21. doi:10.5455/DJVS.42702



MLA (The Modern Language Association) Style

, S.E., Taha, N.M., Lebda, M.A., El Hoffy, H.R., Hashem, and A.E.. "Role of melatonin in preventing thioacetamide induced liver injury in rats." Damanhour Journal of Veterinary Sciences 1.2 (2019), 18-21. Print. doi:10.5455/DJVS.42702



APA (American Psychological Association) Style

, S.E., ., Taha, ., N.M., ., Lebda, ., M.A., ., Hoffy, . E., H.R., ., Hashem, . & A.E., . (2019) Role of melatonin in preventing thioacetamide induced liver injury in rats. Damanhour Journal of Veterinary Sciences, 1 (2), 18-21. doi:10.5455/DJVS.42702